Water → HCID 20446168, compound

HRID 2418347Notes

Reaction equation

HRID 2418347 reaction equation
[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([O:20]CC)=[O:19].[OH-].[Na+].O>C1C=CC=CC=1>[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=[O:19]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 20446231HCID 20446231, compound

Product 1

HCID 20446168HCID 20446168, compoundYield 63.6%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of ethyl 2-[2-amino-3-(3,4-dichlorphenoxy)phenyl]acetate (7.2 g.), sodium hydroxide (1.7 g.) and water (50 ml.) was treated in a similar manner to that of Example 5-(2). The resultant residue was pulverized with benzene, and the precipitates were collected by filtration and dried to give 2-[2-amino-3-(3,4-dichlorophenoxy)phenyl]acetic acid (4.2 g.). mp 125° to 127° C.

Workup

  1. additionwas treated in a similar manner to that of Example 5-(2)
  2. filtrationthe precipitates were collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-837821fc120e42aa96db4c515f8612b4
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

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