Sodium Hydroxide → HCID 20446150, compound

HRID 2418348Notes

Reaction equation

HRID 2418348 reaction equation
[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([O:20]CC)=[O:19].[OH-].[Na+]>O>[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:10]=[C:11]([Cl:16])[CH:12]=[C:13]([Cl:15])[CH:14]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20446180HCID 20446180, compound

Product 1

HCID 20446150HCID 20446150, compoundYield 71.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of ethyl 2-[2-amino-3-(3,5-dichlorophenoxy)phenyl]acetate (6.9 g.), sodium hydroxide (1.6 g.) and water (50 ml.) was treated in a similar manner to that of Example 5-(2). The resultant residue (6.2 g.) was crystallized with a mixture of ethyl acetate and n-hexane to give white crystals of 2-[2-amino-3-(3,5-dichlorophenoxy)phenyl]acetic acid (4.5 g.). mp 113° to 115° C.

Workup

  1. additionwas treated in a similar manner to that of Example 5-(2)
  2. customThe resultant residue (6.2 g.) was crystallized with a mixture of ethyl acetate and n-hexane

Sources & evidence

ORD record
ord-1c268c85a54a453289ad1fc9d5b34bae
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

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