反应详情

A solution of ethyl 2-[2-nitro-3-(2-fluorophenoxy)phenyl]acetate in methanol (50 ml) was added to a solution of potassium hydroxide (20 g) in methanol (50 ml) with stirring under ice-cooling, and the mixture was stirred at room temperature for 30 minutes. Water (700 ml) was added to the reaction mixture and the resultant aqueous solution was adjusted to pH 2.0 with conc. hydrochloric acid. The precipitating crystals were collected by filtration, washed with water and recrystallized from a mixture of ethyl acetate and n-hexane (1:1) to give 2-[2-nitro-3-(2-fluorophenoxy)phenyl]acetic acid (31.9 g). mp 144°-146° C.

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 30 minutes
3. filtrationThe precipitating crystals were collected by filtration
4. washwashed with water
5. customrecrystallized from a mixture of ethyl acetate and n-hexane (1:1)