Ammonium Chloride → HCID 20446246, compound

HRID 2418386Notes

Reaction equation

HRID 2418386 reaction equation
[Cl-].[NH4+].[N+:3]([C:6]1[C:11]([S:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:20][C:21]([O:23]CC)=O)([O-])=O>C(O)C.O.[Fe]>[O:23]=[C:21]1[CH2:20][C:7]2[C:6](=[C:11]([S:12][C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[CH:10]=[CH:9][CH:8]=2)[NH:3]1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 20446300HCID 20446300, compound

Product 1

HCID 20446246HCID 20446246, compoundYield 88%

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of iron powder (21.6 g) and ammonium chloride (2.2 g) in ethanol (200 ml) and water (75 ml) and ethyl 2-[2-nitro-3-(4-chlorophenylthio)phenyl]acetate (21.6 g) were treated in a similar manner to that of Preparation 28-(1) to give 2-oxo-7-(4-chlorophenylthio)indoline (14.9 g). mp 186°-188° C.

Workup

  1. additionwere treated in a similar manner to that
  2. customof Preparation 28-(1)

Sources & evidence

ORD record
ord-1ac38fb39664404e81dc2011a39dad6f
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

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