Hydrochloric Acid → HCID 131713705, compound

HRID 2418533Notes

Reaction equation

HRID 2418533 reaction equation
[N:1](C(OC(C)(C)C)=O)([CH2:3][C:4]([NH:6][C@H:7]([C:12]([NH:14][C@H:15]([C:20]([NH2:22])=[O:21])[CH2:16][CH2:17][S:18][CH3:19])=[O:13])[CH2:8][CH:9]([CH3:11])[CH3:10])=[O:5])[CH3:2].Cl>C(O)(=O)C>[NH:1]([CH2:3][C:4]([NH:6][C@H:7]([C:12]([NH:14][C@H:15]([C:20]([NH2:22])=[O:21])[CH2:16][CH2:17][S:18][CH3:19])=[O:13])[CH2:8][CH:9]([CH3:11])[CH3:10])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131713706HCID 131713706, compound

Product 1

HCID 131713705HCID 131713705, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Condensation of BocSarOPFP (3.43 g.) and HLeu-MetNH2 (Example 1, 2.98 g.) by the activated ester method gave BocSar-Leu-MetNH2 in 75% yield. De-t-butoxycarbonylation of BocSar-Leu-MetNH2 (3.04 g.) using hydrogen chloride in acetic acid gave HSar-Leu-MetNH2 in 100% yield.

Sources & evidence

ORD record
ord-48793d64d24542eb8d8c0c364cef52aa
Source dataset
uspto-grants-1984_09
Patent number
US04472305

Reaction notes

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