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HRID2418549

反应详情

EQUATION

反应方程式

HRID 2418549 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：CC(C)(C)OC(=O)NCC(=O)O
HCID78288

Glycine, N-[(1,1-dimethylethoxy)carbonyl]-

C7H13NO4

结构：O=C1CCC(=O)N1O
HCID80170

2,5-Pyrrolidinedione, 1-hydroxy-

C4H5NO3

结构：CSCC[C@H](NC(=O)[C@@H](N)CCC(C)C)C(N)=O.Cl
HCID131713703

未命名化合物

PRODUCTS

生成物

1
结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)OC(C)(C)C)C(N)=O
HCID15602549

未命名化合物

收率 51%

PROCEDURE

实验过程

Condensation of BocGlyOH (4.4 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 7.5 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocGly-Leu-MetNH2 in 51% yield. De-t-butoxycarbonylation of BocGly-Leu-MetNH2 using hydrogen chloride in acetic acid gave HGly-Leu-MetNH2 hydrochloride salt in 56% yield.