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HRID2418571

反应详情

EQUATION

反应方程式

HRID 2418571 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CSCC[C@H](NC(=O)[C@@H](N)CCC(C)C)C(N)=O.Cl
HCID131713703

未命名化合物

结构：CC(C)(C)OC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)NN
HCID131713747

未命名化合物

结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(N)=O
HCID131713748

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1)C(N)=O
HCID131713746

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Condensation of BocPro-Phe-Phe-Glu(tBu)NHNH2 (0.570 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 0.560 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) have BocPro-Phe-Phe-Glu(tBu)-Leu-MetNH2 in 77% yield. De-t-butylation and de-t-butoxycarbonylation of BocPro-Phe-Phe-Glu(tBu)-Leu-MetNH2 using hydrogen chloride in acetic acid gave HPro-Phe-Phe-Glu-Leu-MetNH2, which was isolated as the amorphous off-white solid hydrochloride salt in 38% yield.