HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 131713754, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 10576139 | HCID 10576139 | — |
| Product | HCID 131713754 | HCID 131713754 | 61% |
Reaction Steps
Condensation of BocDTrpOPFP (7.06 g.) and HPheOMe hydrochloride salt (3.24 g.) by the activated ester method gave BocDTrp-PheOMe in 81% yield. De-t-butoxycarbonylation of BocDTrp-PheOMe (5.0 g.) using trifluoroacetic acid gave HDTrp-PheOMe trifluoroacetate salt in 61% yield. Condensation of BocProOPFP (2.23 g.) and HDTrp-PheOMe trifluoroacetate salt (2.75 g.) by the activated ester method gave BocPro-DTrp-PheOMe in 74% yield. Hydrazinolysis of BocPro-DTrp-PheOMe (2.00 g.) gave BocPro-DTrp-PheNHNH2 yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-ccc90081ddb148deb554523f1f77de58 |
| Source note | uspto-grants-1984_09 |