HRID2418574

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C

HCID10576139

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12.O=C(O)C(F)(F)F

HCID131713754

未命名化合物

收率 61%

PROCEDURE

实验过程

Condensation of BocDTrpOPFP (7.06 g.) and HPheOMe hydrochloride salt (3.24 g.) by the activated ester method gave BocDTrp-PheOMe in 81% yield. De-t-butoxycarbonylation of BocDTrp-PheOMe (5.0 g.) using trifluoroacetic acid gave HDTrp-PheOMe trifluoroacetate salt in 61% yield. Condensation of BocProOPFP (2.23 g.) and HDTrp-PheOMe trifluoroacetate salt (2.75 g.) by the activated ester method gave BocPro-DTrp-PheOMe in 74% yield. Hydrazinolysis of BocPro-DTrp-PheOMe (2.00 g.) gave BocPro-DTrp-PheNHNH2 yield.