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HRID2418582

反应详情

EQUATION

反应方程式

HRID 2418582 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)OC(C)(C)C)C(N)=O
HCID15602549

未命名化合物

PRODUCTS

生成物

1
结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN)C(N)=O
HCID7021411

Glycyl-L-leucyl-L-methioninamide

C13H26N4O3S

收率 77%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Condensation of BocGlyOPFP (7.2 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 10.2 g.) by the actived ester method gave BocGly-Leu-MetNH2 in 73% yield. De-t-butoxycarbonylation of BocGly-Leu-MetNH2 (9.38 g.) using hydrogen chloride in acetic acid gave HGly-Leu-MetNH2 in 77% yield. Condensation of BocD, LBpaOH (1.6 g.) and H-Gly-Leu-MetNH2 (2.13 g.) by the mixed anhydride method using diphenylphosphinyl chloride gave BocD,LBpa-Gly-Leu-MetNH2, de-t-butoxycarbonylation of which (1.1 g.) using hydrogen chloride in acetic acid gave HD, LBpa-Gly-Leu-MetNH2 in 30% overall yield.