HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl chloroformate → BocDPhe-Leu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | Boc-D-phenylalanine | HCID 637610 | — |
| Reactant | HLeu-MetNH2 hydrochloride | HCID 131713703 | — |
| Product | BocDPhe-Leu-MetNH2 | HCID 131713767 | 57% |
Reaction Steps
Condensation of BocDPheOH (2.65 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 2.98 g.) by the mixed anhydride method using isobutyl chloroformate gave BocDPhe-Leu-MetNH2 in 57% yield. De-t-butoxycarbonylation of BocDPhe-Leu-MetNH2 (2.7 g.) using hydrogen chloride in ethyl acetate gave HDPhe-Leu-MetNH2 hydrochloride salt in 82% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-a05df0a55dc341ffa694100e0771641d |
| Source note | uspto-grants-1984_09 |