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HRID2418585

反应详情

EQUATION

反应方程式

HRID 2418585 的结构方程式

REACTANTS

反应物

3
结构：CC(C)COC(=O)Cl
HCID62365

Isobutyl chloroformate

C5H9ClO2

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O
HCID637610

Boc-D-phenylalanine

C14H19NO4

结构：CSCC[C@H](NC(=O)[C@@H](N)CCC(C)C)C(N)=O.Cl
HCID131713703

未命名化合物

PRODUCTS

生成物

1
结构：CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(N)=O
HCID131713767

未命名化合物

收率 57%

PROCEDURE

实验过程

Condensation of BocDPheOH (2.65 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 2.98 g.) by the mixed anhydride method using isobutyl chloroformate gave BocDPhe-Leu-MetNH2 in 57% yield. De-t-butoxycarbonylation of BocDPhe-Leu-MetNH2 (2.7 g.) using hydrogen chloride in ethyl acetate gave HDPhe-Leu-MetNH2 hydrochloride salt in 82% yield.