HuagongsheHuagongshe Chemistry Print Report · For research reference only
BocPro-DPhe-PheNHNH2 → BocPro-DPhe-Phe-DPhe-Leu-MetNH2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | BocPro-DPhe-PheNHNH2 | HCID 131713729 | — |
| Reactant | HDPhe-Leu-MetNH2 hydrochloride | HCID 131713768 | — |
| Product | BocPro-DPhe-Phe-DPhe-Leu-MetNH2 | HCID 131713770 | 91% |
Reaction Steps
Condensation of BocPro-DPhe-PheNHNH2 (2.09 g.) and HDPhe-Leu-MetNH2 hydrochloride salt (1.78 g.) by the acyl azide method (Yajima et al., Chem. Pharm. Bull., vol. 19, p. 1900, 1971) gave BocPro-DPhe-Phe-DPhe-Leu-MetNH2 in 91% yield. De-t-butoxycarbonylation of BocPro-DPhe-Phe-DPhe-Leu-MetNH2 (2.32 g.) using hydrogen chloride in ethyl acetate gave HPro-DPhe-Phe-DPhe-Leu-MetNH2, which was isolated as the amorphous white solid phosphate (1:1) salt dihydrate in 44% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472305 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-2c061801ee6d4c23be4bcc4d0dc1cd9e |
| Source note | uspto-grants-1984_09 |