反应详情

To a stirred solution of the crude 3-azido-3-(6-(trifluoromethyl)pyridin-3-yl)propanal (5.0 g, 20.5 mmol) in tetrahydrofuran (100 mL) at 0° C. was added sodium tetrahydroborate (1.52 g, 40.1 mmol). The mixture was stirred at room temperature for 10 minutes. After completion of the reaction, brine was added and the mixture was extracted with ether. The organic layer was dried and concentrated to afford a crude oil which was purified by silica gel chromatography to afford a light yellow oil.

1. additionwas added
2. extractionthe mixture was extracted with ether
3. customThe organic layer was dried
4. concentrationconcentrated
5. customto afford a crude oil which
6. customwas purified by silica gel chromatography
7. customto afford a light yellow oil