Cyclohexyl isothiocyanate → HCID 13339832, compound

HRID 2418640Notes

Reaction equation

HRID 2418640 reaction equation
[C:1]1([NH:7][CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:12]1([N:18]=[C:19]=[S:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C(O)C>[C:1]1([N:7]2[CH2:8][C:9](=[O:11])[N:18]([CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[C:19]2=[S:20])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14289Cyclohexyl isothiocyanateHCID 66025N-Phenylglycine

Product 1

HCID 13339832HCID 13339832, compoundYield 40.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of N-phenyl glycine (15.1 g, 0.1M) and cyclohexylisothiocyanate (21.2 g, 0.15M) was heated at 100° C. for 8 hours and then allowed to stand at room temperature overnight. The reaction mixture was placed in about 50 ml of ethanol, collected by filtration and recrystallized from ethanol to produce 11 grams (0.047M) of the above-identified product having a melting point of 156° C.

Workup

  1. filtrationcollected by filtration
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-5c792537c92745a4afd31a7145d2e65c
Source dataset
uspto-grants-1984_09
Patent number
US04473393

Reaction notes

Loading…