Phenyl Isothiocyanate → HCID 787340, compound

HRID 2418641Notes

Reaction equation

[C:1]1([NH:7][CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:12]1([N:18]=[C:19]=[S:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[C:1]1([N:7]2[CH2:8][C:9](=[O:11])[N:18]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:19]2=[S:20])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 7673Phenyl Isothiocyanate

HCID 66025N-Phenylglycine

Product 1

HCID 787340HCID 787340, compoundYield 37.3%

Conditions

Temperature: 150 °C

Procedure

A mixture of N-phenyl glycine (7.5 gram, 0.05 mole) and phenylisothiocyanate (8 grams, 0.06 mole) was heated at 150° C. for 3 hours with stirring. The reaction mixture solidified, was ground up, and crystallized from toluene, twice, to produce 5 grams (37% yield) of the above-identified product having a melting point of about 214° C.

Workup

customcrystallized from toluene

Sources & evidence

ORD record: ord-48ef726bf58e4865aef2abdfeebc14d2
Source dataset: uspto-grants-1984_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04473393

Reaction notes

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