Water → HCID 178448097, compound

HRID 2418657Notes

Reaction equation

HRID 2418657 reaction equation
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10](Cl)=[O:11])[CH2:6][CH2:5]1)[CH2:2][CH3:3].[F:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1.N1C=CC=CC=1.O>C1(C)C=CC=CC=1>[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]([O:26][C:23]2[CH:24]=[CH:25][C:20]([C:17]3[CH:16]=[CH:15][C:14]([F:13])=[CH:19][CH:18]=3)=[CH:21][CH:22]=2)=[O:11])[CH2:6][CH2:5]1)[CH2:2][CH3:3]

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 3454204-Fluoro-4'-hydroxybiphenylHCID 178448094HCID 178448094, compound

Product 1

HCID 178448097HCID 178448097, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 18.8 g of trans-4-propylcyclohexanecarbonyl chloride in 20 ml of toluene was added dropwise to a solution of 18.8 of 4'-fluoro-4-hydroxybiphenyl and 8 g of pyridine in 25 ml of toluene and the mixture was heated, with stirring, at 80° for 20 hours. After cooling down water was added, the phases were separated, the organic phase was washed, evaporated and 4'-fluorobiphenyl-4-yl trans-4-propylcyclohexanecarboxylate was obtained, m.p. 96°, c.p. 174°.

Workup

  1. temperaturethe mixture was heated
  2. additionwas added
  3. customthe phases were separated
  4. washthe organic phase was washed
  5. customevaporated

Sources & evidence

ORD record
ord-0a0d018d916b47018bba32aad8f186a0
Source dataset
uspto-grants-1984_09
Patent number
US04473487

Reaction notes

Loading…