Trimethyl phosphite → HCID 86739661, compound

HRID 2418666Notes

Reaction equation

HRID 2418666 reaction equation
[P:1]([O:6][CH3:7])([O:4][CH3:5])[O:2]C.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16](Cl)=[O:17])=[CH:11][CH:10]=1>C(OCC)C>[CH3:5][O:4][P:1]([C:16]([OH:17])=[CH:15][C:12]1[CH:13]=[CH:14][C:9]([Cl:8])=[CH:10][CH:11]=1)(=[O:2])[O:6][CH3:7]

Participants

4

Reactant 2

HCID 8472Trimethyl phosphiteHCID 906924-Chlorophenylacetyl chloride

Product 1

HCID 86739661HCID 86739661, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

At 0° C., a solution of 6.9 g of trimethyl phosphite in 20 ml of diethyl ether is added dropwise under agitation to a solution of 9.5 g of 4-chlorophenylacetic acid chloride in 50 ml of diethyl ether. The mixture is agitated for another 90 minutes, the thus-obtained precipitate is vacuum-filtered, yielding 9.3 g (71%) of 2-(4-chlorophenyl)-1-hydroxyethenephosphonic acid dimethyl ester, mp 89°-92° C.

Workup

  1. filtrationthe thus-obtained precipitate is vacuum-filtered

Sources & evidence

ORD record
ord-d7ab55b952154eddb1682c97de77ee09
Source dataset
uspto-grants-1984_09
Patent number
US04473560

Reaction notes

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