反应详情

温度

180 °C

To a stirred solution of (R)-1-(6-(trifluoromethyl)pyridin-3-yl)ethanamine dihydrochloride (44 mg, 0.17 mmol) and N,N-diisopropylethylamine (73 μL, 0.42 mmol) in acetonitrile (1.1 mL) was added 4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine (30 mg, 0.1 mmol). The reaction was capped and heated in the microwave for 10 hours at 180° C. The reaction mixture was quenched with excess water and allowed to stir for 10-15 minutes. The precipitated product was filtered, washed with water and dried in vacuum oven to obtain the title compound as a light tan solid.

1. customThe reaction was capped
2. customThe reaction mixture was quenched with excess water
3. filtrationThe precipitated product was filtered
4. washwashed with water
5. customdried in vacuum oven