反应详情

92.1 g (0.353 mol) of diphenyl(4-pyridyl)methyl alcohol recrystallized from chloroform and 800 ml of simple-distillation benzene were charged in a 2-l three-necked flask provided with a stirrer and reflux condenser. The mixture was treated at 50° C. to form a suspension. 29.6 ml (0.407 mol) of thionyl chloride was poured in the suspension and the mixture was stirred under reflux for 1 h. The resulting solution was cooled to room temperature. 72.5 ml (0.522 mol) of triethylamine was added thereto and the mixture was stirred for 7 h. The reaction solution was filtered and the filtrate was concentrated to obtain crude diphenyl(4-pyridyl)methyl chloride.

1. additionwere charged in a 2-l three-necked flask
2. customprovided with a stirrer
3. temperaturereflux condenser
4. additionThe mixture was treated at 50° C.
5. customto form a suspension
6. temperatureunder reflux for 1 h
7. stirringthe mixture was stirred for 7 h
8. filtrationThe reaction solution was filtered
9. concentrationthe filtrate was concentrated