反应详情

A reaction mixture of 4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine (120 mg, 0.46 mmol) and (R)-1-(2-methylpyrimidin-5-yl)ethanamine (120 mg, 0.87 mmol) in acetonitrile (1 mL) and N,N-diisopropylethylamine (500 μL, 3 mmol) was subjected to microwave irradiation at 185° C. for 3.5 h. The reaction mixture was concentrated and the residue was purified by semi-prep HPLC (100×20.2 mm, C18 column; 30-55% CH3CN-water [10 mM Et2NH]) to give a light color solid. LC-MS: 362.4 [M+H]+;

1. customirradiation at 185° C. for 3.5 h
2. concentrationThe reaction mixture was concentrated
3. customthe residue was purified by semi-prep HPLC (100×20.2 mm, C18 column; 30-55% CH3CN-water [10 mM Et2NH])
4. customto give a light color solid