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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418853Generated: October 26, 2026

4-Cyanopyridine → 2-(Difluoromethyl)isonicotinonitrile

https://huagongshe.com/reaction/2418853

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-CyanopyridineHCID 7506—
ReactantCID 89600919HCID 89600919—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
SolventWaterHCID 962—
SolventDichloromethaneHCID 6344—
Product2-(Difluoromethyl)isonicotinonitrileHCID 7540628465%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja211422g
Source datasetMinisci dataset from Roche
ORD IDord-2d6510a99676427baa7b832568afd7d7
Source noteMinisci dataset from Roche