4-Cyanopyridine → 2-(Difluoromethyl)isonicotinonitrile

HRID 2418853Notes

Reaction equation

HRID 2418853 reaction equation
N#Cc1ccncc1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>N#Cc1ccnc(C(F)F)c1

Participants

7

Reactant 2

HCID 75064-CyanopyridineHCID 89600919CID 89600919

Product 1

HCID 754062842-(Difluoromethyl)isonicotinonitrileYield 65%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-2d6510a99676427baa7b832568afd7d7
Source dataset
Minisci dataset from Roche

Reaction notes

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