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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418859Generated: October 26, 2026

Isonicotinamide → 2,6-Bis(difluoromethyl)pyridine-4-carboxamide

https://huagongshe.com/reaction/2418859

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsonicotinamideHCID 15074—
ReactantCID 89600919HCID 89600919—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
SolventWaterHCID 962—
SolventDichloromethaneHCID 6344—
Product2,6-Bis(difluoromethyl)pyridine-4-carboxamideHCID 16748381050%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja211422g
Source datasetMinisci dataset from Roche
ORD IDord-c9894bad8c2d44ef8f6d5e65cc06c333
Source noteMinisci dataset from Roche