Isonicotinamide → 2,6-Bis(difluoromethyl)pyridine-4-carboxamide

HRID 2418859Notes

Reaction equation

HRID 2418859 reaction equation
NC(=O)c1ccncc1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>NC(=O)c1cc(C(F)F)nc(C(F)F)c1

Participants

7

Reactant 2

HCID 15074IsonicotinamideHCID 89600919CID 89600919

Product 1

HCID 1674838102,6-Bis(difluoromethyl)pyridine-4-carboxamideYield 50%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-c9894bad8c2d44ef8f6d5e65cc06c333
Source dataset
Minisci dataset from Roche

Reaction notes

Loading…