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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418868Generated: November 1, 2026

2-Pyrimidinecarboxylic acid, methyl ester → Methyl 5-(difluoromethyl)pyrimidine-2-carboxylate

https://huagongshe.com/reaction/2418868

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyrimidinecarboxylic acid, methyl esterHCID 3613871—
ReactantCID 89600919HCID 89600919—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
SolventWaterHCID 962—
SolventDichloromethaneHCID 6344—
ProductMethyl 5-(difluoromethyl)pyrimidine-2-carboxylateHCID 8960153350%
ProductMethyl 4-(difluoromethyl)pyrimidine-2-carboxylateHCID 8960273212%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja211422g
Source datasetMinisci dataset from Roche
ORD IDord-99cd4723753e47f89a2586684acfa965
Source noteMinisci dataset from Roche