2-Pyrimidinecarboxylic acid, methyl ester → Methyl 5-(difluoromethyl)pyrimidine-2-carboxylate

HRID 2418868Notes

Reaction equation

HRID 2418868 reaction equation
COC(=O)c1ncccn1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>COC(=O)c1ncc(C(F)F)cn1.COC(=O)c1nccc(C(F)F)n1

Participants

8

Reactant 2

HCID 36138712-Pyrimidinecarboxylic acid, methyl esterHCID 89600919CID 89600919

Product 2

HCID 89601533Methyl 5-(difluoromethyl)pyrimidine-2-carboxylateYield 50%HCID 89602732Methyl 4-(difluoromethyl)pyrimidine-2-carboxylateYield 12%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-99cd4723753e47f89a2586684acfa965
Source dataset
Minisci dataset from Roche

Reaction notes

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