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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418870Generated: November 2, 2026

1,3,4-Thiadiazol-2-amine → 5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine

https://huagongshe.com/reaction/2418870

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3,4-Thiadiazol-2-amineHCID 19909—
ReactantCID 89600919HCID 89600919—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
SolventWaterHCID 962—
SolventDichloromethaneHCID 6344—
Product5-(Difluoromethyl)-1,3,4-thiadiazol-2-amineHCID 2181908940%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja211422g
Source datasetMinisci dataset from Roche
ORD IDord-49f9caf458e4464ab9e52809e2b0ee0f
Source noteMinisci dataset from Roche