1,3,4-Thiadiazol-2-amine → 5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine

HRID 2418870Notes

Reaction equation

HRID 2418870 reaction equation
Nc1nncs1.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>Nc1nnc(C(F)F)s1

Participants

7

Reactant 2

HCID 199091,3,4-Thiadiazol-2-amineHCID 89600919CID 89600919

Product 1

HCID 218190895-(Difluoromethyl)-1,3,4-thiadiazol-2-amineYield 40%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-49f9caf458e4464ab9e52809e2b0ee0f
Source dataset
Minisci dataset from Roche

Reaction notes

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