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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418878Generated: October 28, 2026

6-Chloropurine → 6-Chloro-2,8-bis(difluoromethyl)-9H-purine

https://huagongshe.com/reaction/2418878

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-ChloropurineHCID 5359277—
ReactantCID 89600919HCID 89600919—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
SolventWaterHCID 962—
SolventDichloromethaneHCID 6344—
Product6-Chloro-2,8-bis(difluoromethyl)-9H-purineHCID 10156207830%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/ja211422g
Source datasetMinisci dataset from Roche
ORD IDord-c93fd26be93048ac80a5ab2b4395e29d
Source noteMinisci dataset from Roche