6-Chloropurine → 6-Chloro-2,8-bis(difluoromethyl)-9H-purine

HRID 2418878Notes

Reaction equation

HRID 2418878 reaction equation
Clc1ncnc2nc[nH]c12.O=S(O)C(F)F.[Zn]>CC(C)(C)OO.ClCCl.O.O=C(O)C(F)(F)F>FC(F)c1nc(Cl)c2[nH]c(C(F)F)nc2n1

Participants

7

Reactant 2

HCID 53592776-ChloropurineHCID 89600919CID 89600919

Product 1

HCID 1015620786-Chloro-2,8-bis(difluoromethyl)-9H-purineYield 30%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-c93fd26be93048ac80a5ab2b4395e29d
Source dataset
Minisci dataset from Roche

Reaction notes

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