Ethyl isonicotinate → HCID 178468959, compound

HRID 2418889Notes

Reaction equation

HRID 2418889 reaction equation
CCOC(=O)c1ccncc1.O=S(O)CF.[Zn]>CC(C)(C)OO.Fc1c(F)c(F)c(C(F)(F)F)c(F)c1F.O>CCOC(=O)c1cc(CF)nc(CF)c1.CCOC(=O)c1ccnc(CF)c1

Participants

7

Reactant 2

HCID 15291Ethyl isonicotinateHCID 178527420HCID 178527420, compound

Product 2

HCID 75530092Ethyl 2-(Fluoromethyl)IsonicotinateYield 4%HCID 178468959HCID 178468959, compoundYield 69%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 962WaterSolventHCID 9906OctafluorotolueneSolvent

Conditions

Temperature
50 °C

Sources & evidence

ORD record
ord-02943d791f4d471195f47a5b366e8b27
Source dataset
Minisci dataset from Roche

Reaction notes

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