3-Chloro-6-methoxypyridazine → 3-Chloro-6-methoxy-4-propan-2-ylpyridazine

HRID 2418896Notes

Reaction equation

HRID 2418896 reaction equation
CC(C)S(=O)O.COc1ccc(Cl)nn1.[Zn]>CC(C)(C)OO.CS(C)=O.O>COc1cc(C(C)C)c(Cl)nn1.COc1nnc(Cl)cc1C(C)C

Participants

7

Reactant 2

HCID 744033-Chloro-6-methoxypyridazineHCID 117778686Propane-2-sulfinic acid;ZINC

Product 2

HCID 1350754806-Chloro-3-methoxy-4-propan-2-ylpyridazineYield 4%HCID 1624021723-Chloro-6-methoxy-4-propan-2-ylpyridazineYield 45%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Sources & evidence

ORD record
ord-0589f71f95eb4300a6f0870d4c0a9aa9
Source dataset
Minisci dataset from Roche

Reaction notes

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