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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418901Generated: October 26, 2026

6-Chloropurine → 6-chloro-2-(difluoromethyl)-8-propan-2-yl-7H-purine

https://huagongshe.com/reaction/2418901

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-ChloropurineHCID 5359277—
ReactantPropane-2-sulfinic acid;ZINCHCID 117778686—
Reagenttert-Butyl hydroperoxideHCID 6410—
ReagentTrifluoroacetic acidHCID 6422—
Solvent1,2-DichloroethaneHCID 11—
SolventWaterHCID 962—
Product6-chloro-2-(difluoromethyl)-8-propan-2-yl-7H-purineHCID 8960155223%

Reaction Conditions

Temperature50 °C

Provenance & Evidence

DOI10.1038/nature11680
Source datasetMinisci dataset from Roche
ORD IDord-313eecc3ba344c5abbe0fa0e5c45126a
Source noteMinisci dataset from Roche