6-Chloropurine → 6-chloro-2-(difluoromethyl)-8-propan-2-yl-7H-purine

HRID 2418901Notes

Reaction equation

HRID 2418901 reaction equation
CC(C)S(=O)O.Clc1ncnc2nc[nH]c12.[Zn]>CC(C)(C)OO.ClCCCl.O.O=C(O)C(F)(F)F>CC(C)c1nc2nc(C(F)F)nc(Cl)c2[nH]1

Participants

7

Reactant 2

HCID 53592776-ChloropurineHCID 117778686Propane-2-sulfinic acid;ZINC

Product 1

HCID 896015526-chloro-2-(difluoromethyl)-8-propan-2-yl-7H-purineYield 23%

Reagents, catalysts & solvents 4

HCID 6410tert-Butyl hydroperoxideReagentHCID 6422Trifluoroacetic acidReagentHCID 111,2-DichloroethaneSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Sources & evidence

ORD record
ord-313eecc3ba344c5abbe0fa0e5c45126a
Source dataset
Minisci dataset from Roche

Reaction notes

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