3-Acetyl-5-bromopyridine → 1-(5-Bromo-6-(trifluoromethyl)pyridin-3-yl)ethanone

HRID 2418907Notes

Reaction equation

HRID 2418907 reaction equation
CC(=O)c1cncc(Br)c1.O=S(O)C(F)(F)F.[Zn]>CC(C)(C)OO.ClCCl.O>CC(=O)c1cnc(C(F)(F)F)c(Br)c1

Participants

6

Reactant 2

HCID 8204233-Acetyl-5-bromopyridineHCID 89601280CID 89601280

Product 1

HCID 1301150841-(5-Bromo-6-(trifluoromethyl)pyridin-3-yl)ethanoneYield 46%

Reagents, catalysts & solvents 3

HCID 6410tert-Butyl hydroperoxideReagentHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-532695b758824fa9b5b376507ef24a88
Source dataset
Minisci dataset from Roche

Reaction notes

Loading…