反应详情

9.35 g (0.06 mole) of methyl 1-methylcarbonyl-2-ethoxyvinyl ketone were added dropwise to a suspension of 10.3 g (0.05 mole) of 3-amino-2,5-dichlorobenzoic acid in 40 ml of ether. The mixture was stirred for a further 5 hours at room temperature and the precipitate was then filtered off and washed with acetonitrile. 12 g (76% of theory) of 3-[2,2-bis-(methylcarbonyl)-vinylamino]-2,5-dichlorobenzoic acid were obtained in the form of colourless crystals of melting point 244°-246° C.

1. filtrationthe precipitate was then filtered off
2. washwashed with acetonitrile