Hydrochloric Acid → 1-Phenylethane-1,2-diamine--hydrogen chloride (1/2)

HRID 2419036Notes

Reaction equation

HRID 2419036 reaction equation
[C:1]1([CH:7]([NH:13]C(=O)C)[CH2:8][NH:9]C(=O)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:17]>>[ClH:17].[ClH:17].[C:1]1([CH:7]([NH2:13])[CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 12698223N,N'-(1-Phenylethane-1,2-diyl)diacetamide

Product 1

HCID 126982241-Phenylethane-1,2-diamine--hydrogen chloride (1/2)

Procedure

A mixture of 20 g of 1-phenyl-1-acetylamino-2-acetylaminoethane and 100 ml of concentrated HCl is refluxed for 15 hours. The product separates on chilling and is filtered off, washed with acetone and then with ether to yield 13.7 g of the title C compound. This material is stored in the refrigerator (on standing at room temperature, this material will lose part of the bound HCl).

Workup

  1. temperatureis refluxed for 15 hours
  2. temperatureon chilling
  3. filtrationis filtered off
  4. washwashed with acetone
  5. customwith ether to yield 13.7 g of the title C compound
  6. customon standing at room temperature

Sources & evidence

ORD record
ord-8af3e2512a764d2ba5544c8f51408311
Source dataset
uspto-grants-1978_08
Patent number
US04104400

Reaction notes

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