N-(2-{[(4-Bromo-1,2-thiazol-3-yl)methyl]sulfanyl}ethyl)-N'-methylthiourea → N-cyano-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N"-methylguanidine

HRID 2419071Notes

Reaction equation

HRID 2419071 reaction equation
[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[C:14]([Br:15])=[CH:13][S:12][N:11]=1)=S.[N:16]#[C:17][NH2:18].[Pb]>>[C:17]([NH:18][C:3]([NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[C:14]([Br:15])=[CH:13][S:12][N:11]=1)=[N:2][CH3:1])#[N:16]

Participants

3

Reactant 2

HCID 12923381N-(2-{[(4-Bromo-1,2-thiazol-3-yl)methyl]sulfanyl}ethyl)-N'-methylthioureaHCID 22262466CH2N2Pb

Product 1

HCID 54571990N-cyano-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N"-methylguanidine

Procedure

Reaction of N-methyl-N'-[2-((4-bromo-3-isothiazolyl)-methylthio)ethyl]thiourea with lead cyanamide by the procedure of Example 91 gives N-cyano-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N"-methylguanidine. Hydrolysis of the above product according to the procedure of Example 84 gives N-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N'-methylguanidine hydrochloride.

Sources & evidence

ORD record
ord-c667de18b08d4ff8afb8d871c33d9ae2
Source dataset
uspto-grants-1978_08
Patent number
US04104382

Reaction notes

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