HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-{[(4-Bromo-1,2-thiazol-3-yl)methyl]sulfanyl}ethyl)-N'-methylthiourea → N-cyano-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N"-methylguanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-{[(4-Bromo-1,2-thiazol-3-yl)methyl]sulfanyl}ethyl)-N'-methylthiourea | HCID 12923381 | — |
| Reactant | CH2N2Pb | HCID 22262466 | — |
| Product | N-cyano-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N"-methylguanidine | HCID 54571990 | — |
Reaction Steps
Reaction of N-methyl-N'-[2-((4-bromo-3-isothiazolyl)-methylthio)ethyl]thiourea with lead cyanamide by the procedure of Example 91 gives N-cyano-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N"-methylguanidine. Hydrolysis of the above product according to the procedure of Example 84 gives N-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]-N'-methylguanidine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04104382 |
| Source dataset | uspto-grants-1978_08 |
| ORD ID | ord-c667de18b08d4ff8afb8d871c33d9ae2 |
| Source note | uspto-grants-1978_08 |