Hydrogen Bromide → HCID 12353616, compound

HRID 2419079Notes

Reaction equation

HRID 2419079 reaction equation
Cl.[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:15]C)[C:9]=2[O:13]C)[C:4]1=[O:17].[BrH:18]>>[BrH:18].[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([OH:15])[C:9]=2[OH:13])[C:4]1=[O:17]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 12353614HCID 12353614, compound

Product 1

HCID 12353616HCID 12353616, compound

Procedure

30 parts of 2-amino-5,6-dimethoxy-3,4-dihydro-1(2H)-naphthalenone hydrochloride is subjected to boiling reflux in 500 volume parts of a 47% aqueous solution of hydrogen bromide for 3 hours and, then, concentrated to dryness under reduced pressure. The residue is dissolved in methanol, followed by the addition of ethyl acetate, whereupon crystals separate. Filtrative recovery yields 31 parts of 2-amino-5,6-dihydroxy-3,4-dihydro-1(2H)-naphthalenone hydrobromide.

Workup

  1. concentrationconcentrated to dryness under reduced pressure
  2. dissolutionThe residue is dissolved in methanol
  3. additionfollowed by the addition of ethyl acetate, whereupon crystals
  4. customseparate

Sources & evidence

ORD record
ord-98176a7eaf1b4e59be2b61a1e9419d4d
Source dataset
uspto-grants-1978_08
Patent number
US04104402

Reaction notes

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