Hydrogen Bromide → HCID 20316894, compound

HRID 2419084Notes

Reaction equation

HRID 2419084 reaction equation
Cl.[CH:2]1([NH:6][CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:19]C)[C:13]=3[O:17]C)[C:8]2=[O:21])[CH2:5][CH2:4][CH2:3]1.[BrH:22].C(OC(=O)C)(=O)C>>[BrH:22].[CH:2]1([NH:6][CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([OH:19])[C:13]=3[OH:17])[C:8]2=[O:21])[CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 7918Acetic AnhydrideHCID 20316891HCID 20316891, compound

Product 1

HCID 20316894HCID 20316894, compound

Procedure

In a manner similar to that of Reference Example 4, 5.16 parts of 2-cyclobutylamino-5,6-dimethoxy-3,4-dihydro-1(2H)-naphthalenone hydrochloride is hydrolyzed in a mixture of 75 volume parts 48% hydrobromic acid and 15 volume parts acetic anhydride. The procedure yields 4 parts of 2-cyclobutylamino-5,6-dihydroxy-3,4-dihydro-1(2H)-naphthalenone hydrobromide. Melting point: 229°-240° C (decomposition).

Sources & evidence

ORD record
ord-9cbcebc123304651a0e04a2a533a22fe
Source dataset
uspto-grants-1978_08
Patent number
US04104402

Reaction notes

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