反应详情

A solution of 5-chloro-N-methyl-N-phenyl-1,3-benzodithiol-2-iminium iodide (9.97g), 3-aminopropanoic acid, ethyl ester, hydrochloride (3.68g) and anhydrous sodium carbonate (2.54g) in 250 ml of anhydrous dimethylformamide is heated at 120° C under nitrogen for three hours, then left stirring at room temperature for 2 days. The reaction mixture is poured into water (1400 ml) and extracted with three 200 ml portions of dichloromethane. The combined dichloromethane extracts are washed with three 100 ml portions of water, dried over sodium sulfate, and concentrated in vacuo. The resultant oil is chromatographed on silica gel (1000 ml), eluting with dichloromethane/pentane (1:1). The fractions containing product with Rf =0.25 (silica gel, dichloromethane) are concentrated and the resultant solid recrystallized twice from pentane to yield 1.1g of the title compound, melting point 64°-65° C.

1. waitleft
2. extractionextracted with three 200 ml portions of dichloromethane
3. washThe combined dichloromethane extracts are washed with three 100 ml portions of water
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo
6. customThe resultant oil is chromatographed on silica gel (1000 ml)
7. washeluting with dichloromethane/pentane (1:1)
8. additionThe fractions containing product with Rf =0.25 (silica gel, dichloromethane)
9. concentrationare concentrated
10. customthe resultant solid recrystallized twice from pentane