Benzoyl chloride → HCID 20315174, compound

HRID 2419203Notes

Reaction equation

HRID 2419203 reaction equation
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][OH:19])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:20](Cl)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20](=[O:27])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 47132160HCID 47132160, compound

Product 1

HCID 20315174HCID 20315174, compoundYield 92.5%

Procedure

Treatment of 4-benzamido-1-(3-hydroxypropyl) piperidine with benzoyl chloride as in the previous example gave 3.4 grams (92.5% yield) of the title compound, m.p. 146°-7° C. Crystallisation from ethanolic hydrogen chloride afforded the hydrochloride, m.p. 211°-212° C.

Sources & evidence

ORD record
ord-557033e448bc4105b4aeffa9f49ee8da
Source dataset
uspto-grants-1978_08
Patent number
US04105666

Reaction notes

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