Dimethylformamide → 7-(Diethylamino)-2-oxo-2H-chromene-3-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

20 g of dimethylformamide are added dropwise to 40 g of phosphorus oxychloride at 20° - 50° C. The mixture is stirred for 45 minutes at 50° C whilst excluding moisture. A suspension of 42 g of 7-diethylamino-coumarin in 50 g of dimethylformamide is then added, the mixture is warmed to 60° C for 2 hours and poured out onto 400 g of ice water, and the whole is stirred for 2 hours. The crystalline precipitate is filtered off, thoroughly washed with water and dried in vacuo at 70° C. 41 g of 7-diethylamino-coumarin-3-aldehyde are obtained.

Provenance & Evidence