反应详情

温度

50 °C

20 g of dimethylformamide are added dropwise to 40 g of phosphorus oxychloride at 20° - 50° C. The mixture is stirred for 45 minutes at 50° C whilst excluding moisture. A suspension of 42 g of 7-diethylamino-coumarin in 50 g of dimethylformamide is then added, the mixture is warmed to 60° C for 2 hours and poured out onto 400 g of ice water, and the whole is stirred for 2 hours. The crystalline precipitate is filtered off, thoroughly washed with water and dried in vacuo at 70° C. 41 g of 7-diethylamino-coumarin-3-aldehyde are obtained.

1. additionis then added
2. temperaturethe mixture is warmed to 60° C for 2 hours
3. stirringthe whole is stirred for 2 hours
4. filtrationThe crystalline precipitate is filtered off
5. washthoroughly washed with water
6. customdried in vacuo at 70° C