反应详情

温度

50 °C

740 g of an aqueous solution with 50% of glyoxylic acid (5 moles) are mixed with 514 g of chloracetamide (5.5 moles). The mixture is heated to 50° C, then the greater part of the water is removed under vacuum, 1200 g of acetic acid are added and it is cooled on ice. After filtration and drying, 475 g of product are obtained. The product concentrated under vacuum gives 112 g of a second crop, namely a total yield of 69%.

1. customthe greater part of the water is removed under vacuum, 1200 g of acetic acid
2. additionare added
3. temperatureit is cooled on ice
4. filtrationAfter filtration
5. customdrying