反应详情

18 g of gaseous hydrochloric acid at 5° C are dissolved in a solution of 94 g (1 mole) of phenol and 83.8 g (0.5 mole) of chloracetamidoglycolic acid in 120 g of glacial acetic acid. After 8 hours at this temperature and then 16 hours at ambient temperature, the hydrochloric and acetic acids are distilled off at 25 mm of mercury, then the excess phenol at 2 mm of mercury at a temperature below 50° C, 200 ml of nitromethane are added, it is filtered, washed with ethyl ether and dried. 64 g of product are obtained (yield 53% with respect to the chloracetamidoglycolic acid). The product recrystallised in water melts at 187° C.

1. distillation16 hours at ambient temperature, the hydrochloric and acetic acids are distilled off at 25 mm of mercury
2. additionthe excess phenol at 2 mm of mercury at a temperature below 50° C, 200 ml of nitromethane are added
3. filtrationit is filtered
4. washwashed with ethyl ether
5. customdried