Pyridine → HCID 86735887, compound

HRID 2419310Notes

Reaction equation

HRID 2419310 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[N:12]=[CH:13][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:7]1[N:6]([CH3:20])[C:5]2=[O:21].[C:22]1([N:28]=[C:29]=[S:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.N1C=CC=CC=1>O>[CH3:20][N:6]1[C:5](=[O:21])[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([NH:1][C:29]([NH:28][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[S:30])[CH:3]=2)[N:8]2[N:12]=[CH:13][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:7]12

Participants

5

Reactant 3

HCID 1049PyridineHCID 7673Phenyl IsothiocyanateHCID 20315420HCID 20315420, compound

Product 1

HCID 86735887HCID 86735887, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 5 g. (0.018 mole) of ethyl 7-amino-4-methyl-4,5-dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylate and 2.4 g. (0.018 mole) of phenyl isothiocyanate in 250 ml. of pyridine was stirred and heated on a steam bath for about 2 hours, then cooled and diluted with water. The solid which separated was collected to give crude ethyl 4-methyl-7-phenylthioureido-4,5-dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylate which was not further purified but used as such in Example 7T.

Workup

  1. temperatureheated on a steam bath for about 2 hours
  2. temperaturecooled
  3. customThe solid which separated
  4. customwas collected

Sources & evidence

ORD record
ord-f206b1648da847f88238fccc2e5cfb63
Source dataset
uspto-grants-1978_08
Patent number
US04105766

Reaction notes

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