Ethanol → 4-Acetamido-2-ethoxy-thiazole

HRID 2419322Notes

Reaction equation

[C:1]([NH:4][C:5]1[N:6]=[C:7](Br)[S:8][CH:9]=1)(=[O:3])[CH3:2].[Na].[CH2:12]([OH:14])[CH3:13]>>[C:1]([NH:4][C:5]1[N:6]=[C:7]([O:14][CH2:12][CH3:13])[S:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 702Ethanol

HCID 5360545Sodium

HCID 202940434-Acetamido-2-bromo-thiazole

Product 1

HCID 203154854-Acetamido-2-ethoxy-thiazole

Procedure

Following the procedure of Example 1 4-acetamido-2-bromothiazole is treated with sodium in absolute ethanol to give the title compound.

Sources & evidence

ORD record: ord-8980ae9e8d4a4f388f6f94bc7ca3e2f3
Source dataset: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04105773

Reaction notes

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